Evidence for genetic association of RORB with bipolar disorder
نویسندگان
چکیده
منابع مشابه
Evidence for genetic association of RORB with bipolar disorder
BACKGROUND Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder. Microarray studies revealed that expression of t...
متن کاملGenetic Association Studies of Bipolar Disorder
Bipolar disorder is a common and serious mental illness. The occurrence o f mania is central to the diagnosis, but affected individuals typically also suffer episodes of depression. The results o f family, twin and adoption studies argue convincingly for genetic susceptibility to bipolar disorder. Linkage studies conducted at the Molecular Psychiatry Laboratory, UCL have previously implicated t...
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OBJECTIVES The18p11.2 region surrounding the G-olf gene has been linked in several independent studies to bipolar disorder and schizophrenia, yet association studies between G-olf genetic variations and bipolar disorder have been negative. We hypothesized that the linkage in this region might be due to a gene in close physical proximity to G-olf, and we examined variations in the CHMP1.5 gene w...
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BACKGROUND Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute phase response molecule, C-reactive protein (CRP). While the genetic diversity of CRP was amply studied in various pathological settings, little is known in BD. METHODS 568 BD p...
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Bipolar affective disorder (BPAD) is suspected to arise in part from malfunctions of the circadian system, a system that enables adaptation to a daily and seasonally cycling environment. Genetic variations altering functions of genes involved with the input to the circadian clock, in the molecular feedback loops constituting the circadian oscillatory mechanism itself, or in the regulatory outpu...
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ژورنال
عنوان ژورنال: BMC Psychiatry
سال: 2009
ISSN: 1471-244X
DOI: 10.1186/1471-244x-9-70